CAS no.: 7772-98-7
Other names: Sodium thiosulphate, Sodium hyposulfite, Hyposulphite of soda
Sodium Hyposulfite (Na2S2O3), also spelled sodium thiosulphate, is an inorganic compound that
is typically available as the pentahydrate, Na2S2O3·5H2O. The solid is an efflorescent (loses water
readily) crystalline substance that dissolves well in water. It is also called sodium hyposulfite or "hypo".
It is on the World Health Organization's List of Essential Medicines, the most important medications
needed in a basic health system.
2. Technical parameters:
|Item||Photographic grade||Industrial grade||Anhydrous grade|
|Appearance||colorless transparent crystal||colorless transparent crystal||white powder|
|Assay||≥ 99.00%||≥ 98.5%||≥ 97.0%|
|Water Insoluble matter||≤ 0.01%||≤ 0.03%||≤ 0.03%|
|Sulfide||≤ 0.001%||≤ 0.003%||≤ 0.001%|
|Fe||≤ 0.001%||≤ 0.003%||≤ 0.005%|
|Water solution reaction||in accordance with the test||in accordance with the test||----|
1) It has been used as treatment of calciphylaxis in hemodialysis people with end-stage kidney disease.
There is apparently an incompletely understood phenomenon whereby this causes severe metabolic
acidosis in some patients.
2) It is used as an antidote to cyanide poisoning.Thiosulfate serves as a sulfur donor for the conversion
of cyanide to thiocyanate (which can then be safely excreted in the urine), catalyzed by the enzyme
3) It is used in the management of extravasations during chemotherapy. Sodium thiosulfate prevents
alkylation and tissue destruction by providing a substrate for the alkylating agents that have invaded
the subcutaneous tissues.
4) In foot baths for prophylaxis of ringworm, and as a topical antifungal agent for tinea versicolor.
5) In measuring the volume of extracellular body fluid and the renal glomerular filtration rate.
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